hey guys this is dr. Lamott sue research
lead from hv MN
welcome to this episode of research
rather earlier this year a group of
leading ketone scientists looked at diet
changes in modulating brain network
stability so what does that actually
mean
a lot of preliminary studies show that
ketones have neuroprotective properties
these scientists are trying to change a
person's diet and look at the stability
of brain networks to see if it improves
or makes it worse there are two things
that are linked to HBase cognitive
impairment one its insulin resistance
and two its glucose hypometabolism
whether it's the efficiency of glucose
being metabolized in the brain we've
decreased or the less or lowered amount
of glucose being transported to the
brain so this group of scientists
decided to conduct an experiment to look
at the change of diet if it affects
glucose metabolism improves it and
altogether improve brain network
stability so the author started off by
linking type 2 diabetes and cognitive
impairment apparently there are higher
percentage of people with cognitive
impairment amongst diabetic patients
they have lower global cognitive scores
they have decline in memory and they
also have decline in reasoning other
studies in the US and Israel also show
the link between type 2 diabetes and
cognitive dysfunction and this is
evident even in younger adults so all
this while we think that cognitive
impairment it's very different to
metabolic diseases like diabetes or
obesity or insulin resistance but now
we're starting to slowly see the link
between metabolic disease as well as
cognitive impairment and dementia
Alzheimer's and all that so let's let's
dial back a little bit and look at
glucose transport in the brain
conventionally we understand that in the
brain the glucose transporter that is
more prevalent would be glute 3 which is
incident independent that leads us to
think that oh the
brain does not need insulin to function
it does not need all these insulin
dependent transporters such as gluta
which is more prevalent in skeletal
muscles heart and other organs that need
a lot of energy and regulated by insulin
that has changed recently when more
studies show that if you infuse the
brain with insulin independent of
glucose in the absence of glucose it
actually improves memory of Alzheimer's
patients now that just shows us that
with insulin
even without glucose that's being
infused to the brain it does improve the
cognitive function so what can we do
with this sort of information and this
this sort of evidence and that's why
these authors are set out to
investigators and changing someone's
diet to a marketer genic diet or a less
carbohydrate driven diet will help the
stability of the brain networks so let
me bring down this specific study that
was published two months ago earlier
this year they first looked at the data
set that comprises of almost a thousand
patients to really identify what does
brain networks the blue team mean and
they looked at the sustained function of
communication between brain networks and
brain regions and that is how they brain
network stability what they have found
very interestingly enough is that
starting at the age of 47 years the
brain networks ability start to decline
and it Peaks around age of 60 years and
that means even though cognitive
impairment manifestation may not show
you may be able to detect that process
way earlier when you see that these
stabilization of brain networks already
on to the experiment itself where they
have 42 participants so the first
experiment there are 12 participants and
second experiment 30 so let's talk about
the first experiment there were three
arms first arm they looked at standard
diet they do not overnight fast and they
just come in they get scanned second arm
they have the overnight fast group where
the participants are on Sena die but
they fast overnight what two hour
before coming in the next day to be
scanned and third group the people with
ketogenic diet who has been on the diet
for a week all of which were in ketosis
with the definition of more than 0.6
millimolar beta-hydroxybutyrate
in the blood so for the second
experiment there are also three arms all
of which are under sent diet but the
first group is just then a diet with
overnight fast second groups then it
died overnight fast but breaking the
fast with glucose and third group
breaking the fast with ketone esta
there's a chi mm ketone esta so based on
these methods these two experiments I
when I was reading it I was thinking why
are they breaking it down to two parts
and why are they making experiment one
an experiment two and it makes sense
because the first experiment they just
want to see an overall change and diet
with that affect the brain stability and
that's why they looked at extended diets
and diet with fast and ketogenic diet
however what this does not tell us is
the discrepancy between the change of
diets whether the ketogenic diet people
are eating less because of satiety or
they are changing their daily routines
is just as an effect of the holistic
change of diet we don't know that and
that is why they conduct the second
experiment where it is independent of
the diet because everyone is on standard
diet but what makes the difference here
is the glucose bolus as well as the
ketone esta that was used to break the
fast after an overnight fast that
singles out the link between glucose and
ketone metabolism that causes the change
in the brain network stabilization and
that is the information that is the most
relevant to us right now because we want
to see if the change of substrate
metabolism in the brain actually affects
the network stabilization so now let's
dig into the results the most juicy part
of the experiments what have they seen
what have they found and how does this
impact the metabolic world first off
from the analysis of the data set of the
first
before they even go into the experiment
they looked at the stabilization of the
brain networks and as I said earlier at
the age of 47 years they start to see
the manifestation of brain network
destabilization and this is very
critical for us to understand as we
always link cognitive impairment with
aging but little that we know that this
manifestation may happen way earlier
before the symptoms manifest out in a
sort of clinical setting so now the main
event of the entire paper in my opinion
is that the findings that shows ketones
stabilizes the brain networks regardless
whether you're on diet or you're just
breaking the fast prior a ketone ester
okay exogenous ketones in the first
experiment they saw an improved
stabilization of brain network from
standard.i overnight fast and the most
improved would be the ketogenic diet and
this is what I would partially expect
and it reaffirms that ketones are
beneficial for the brain so the second
experiment I'm gonna call it the
exogenous substrate experiment where
everyone is on standard diet but they
are on a overnight fast and they break
the fast with either glucose or ketone
astir the ke group the ketone ester
group showed a significant improvement
in stability basically telling us that
regardless whether you are achieving
ketosis via diet or by exogenous ketones
it is both beneficial to your brain
networks ability they also introduce an
end of one case study where they
administered ke after they've been
taking a large amount of glucose about
75 grams and they still show an
improvement in brain network stability
so this shows how powerful ketone is to
the brain network stability in addition
they also saw an improvement in general
brain activity in the ketogenic group
versus the standard or the overnight
fasted group now let's go to the
discussion points what can we take out
of the entire arm study so by analyzing
the big data set they have concluded
that starting at the age of 47 years
the brain deterioration started to begin
and with the most dramatic changes at
the age of 60 years so now that we know
that if we are vigilant enough we can
actually detect our brain that was the
destabilization and the early
manifestation of cognitive impairment
but at a very early age and most
importantly what this study brings to us
is that there are behavioral and
lifestyle changes that we can adapt in
order to prevent or even delay the onset
of cognitive impairment especially due
to metabolic stress or aging for a long
time now glucose hypometabolism has been
a hallmark of dementia where we know
that the brain is having a lack of
energy because of the deficiency in
glucose metabolism the brain so by
providing the brain cells with a
substrate other than glucose it may very
well arm substitute that energy deficit
and that is why we use ketones where the
brain can easily utilize it to
substitute glucose in order to make up
for the energy deficit now the most
interesting part of the result is that
this does not only work in other
individuals they have also seen positive
results of either exogenous ketones or
ketogenic diet in young adults as well
so you and I can also do this and make
sure that our brain that was are
stabilized before we get old well it has
been a pleasure to talk in research
roundup for HP MN and I really had a lot
of fun reading this paper and of course
it used ketone ester from HP MN which
makes it very relevant to us and how we
can help other people in improving their
metabolic health or improving their
brain network stability still there's a
lot of research to be done and we are
here in hvm n giving our heart and soul
to bring out the science the evidence
and all the relevant papers that use our
product as well as identifying what
ketogenic diet would do to you what keto
esters what exogenous ketones would do
to our tab ilysm and culpers live a
healthier life and aged healthily
Lancel thank you very much for watching
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[Music]
Brain aging is inevitable, but not uniform; every brain ages differently. Are there lifestyle and nutritional interventions we can follow to reduce the rate of decline? A recent study found that those who followed a ketogenic and low-carb diet did indeed see positive results that we can attribute to preventing (perhaps even reversing) cognitive decline as they age. Fascinatingly, even those who followed a standard American diet found that simply ingesting an exogenous ketone ester (H.V.M.N. Ketone Ester) resulted in similar, positive neurological effects. This study, led by Lilianne R. Mujica-Parodi, PhD, and published in PNAS, is titled "Diet modulates brain network stability, a biomarker for brain aging, in young adults". When interviewed about her findings, she is quoted: "...as people get older, their brains start to lose the ability to metabolize glucose efficiently, causing neurons to slowly starve, and brain networks to destabilize. Thus, we tested whether giving the brain a more efficient fuel source, in the form of ketones, either by following a low-carb diet or drinking ketone supplements, could provide the brain with greater energy. Even in younger individuals, this added energy further stabilized brain networks.” In this episode of Research Roundup: Dr. Latt Mansor, H.V.M.N. Research Lead, walks us through the methods, results, and analyses formulated from these experiments. Resources: Study: https://www.pnas.org/content/pnas/117/11/6170.full.pdf Press Article: https://news.stonybrook.edu/newsroom/study-shows-low-carb-diet-may-prevent-reverse-age-related-effects-within-the-brain/ H.V.M.N. Ketone Ester: https://go.hvmn.com/ketone-pod ------------------------------------------------------------------------------ Learn more about H.V.M.N. here: https://www.hvmn.com/pod Subscribe to our channel for weekly videos: https://go.hvmn.com/subscribe-hvmn Join the Official H.V.M.N. Podcast Discord Server by filling out this quick survey: https://go.hvmn.com/discordsurvey Comment below or send a message to podcast@hvmn.com with feedback, questions, and guest suggestions!